Renal Pharmacology

Cardiovascular and Renal Pharmacology

Molecular pharmacology of renal organic anion transporters.

Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine of a wide variety of anionic substrates. Recent studies have shown that organic anion secretion in renal proximal tubule...

Perspectives in Pharmacology Mechanisms of Renal Cell Repair and Regeneration after Acute Renal Failure

In many cases, acute renal failure (ARF) is the result of proximal tubular cell injury and death and can arise in a variety of clinical situations, especially following renal ischemia and drug or toxicant exposure. Although much research has focused on the cellular events leading to ARF, less emphasis has been placed on the mechanisms of renal cell repair and regeneration, although ARF is rever...

Anesthetic Pharmacology Preclinical Pharmacology

Daniel I. Sessler, MD† BACKGROUND: In previous studies, we showed that failure to respond to automated responsiveness monitor (ARM) precedes potentially serious sedationrelated adversities associated with loss of responsiveness, and that the ARM was not susceptible to false-positive responses. It remains unknown, however, whether loss and return of response to the ARM occur at similar sedation ...

Pharmacology.

A very able review of the present status of the pharmacology of cannabis, active substances and synthetic derivatives, has been given by S. Loewe. In conjunction with other recognized American investigators, Roger Adams, E. J. Wollner, et al., he has himself made important contributions to this subject. The large number of animals at his disposal, for example, 2600 experiments carried out on 15...